Cytoplasmic retention signal
WebIntegrins and Signal Transduction. As discussed in Chapters 11 and 12, the integrins are the major receptors responsible for the attachment of cells to the extracellular matrix.At … WebOct 29, 2024 · Our results also show that Transportin-2 (TNPO2, importin-3) enhances the cytoplasmic localisation of ERα, not as a nuclear export receptor, but rather as a cytoplasmic retention factor, while it ...
Cytoplasmic retention signal
Did you know?
WebJan 21, 2024 · Misfolded and/or unassembled secretory and membrane proteins in the endoplasmic reticulum (ER) may be retro-translocated into the cytoplasm, where they undergo ER-associated degradation, or ERAD. The mechanisms by which misfolded proteins are recognized and degraded through this pathway have been studied … WebMar 1, 2004 · Cytoplasmic retention of signal transducers prevails when cells are poised to receive an extracellular signal, and nuclear …
WebThis new understanding of the determinants of nuclear retention and cytoplasmic export provides a deeper understanding of how information flow is regulated in eukaryotic cells. Ultimately these processes promote … WebMay 17, 2005 · Nucleocytoplasmic Shuttling with Periods of Retention: Smads Smad proteins are a family of inducible transcription factors that mediate signals from the transforming growth factor–β (TGF-β) superfamily of ligands, including TGF-β and bone morphogenetic protein (BMP).
WebSep 1, 1994 · Although the cytoplasmic retention signal region is outside the cyclin box, its sequence is well conserved in human cyclin B2, and is both necessary and sufficient to keep cyclin B2 in the cytoplasm. WebMar 1, 2013 · A cytoplasm retention signal would, in theory, not be affected by these interventions, whereas we observed nuclear accumulation of Htt in the setting of inhibition of nuclear export. Given its high degree of evolutionary conservation, beyond the four amino acid NES motif, it is highly plausible that N17 contains overlapping, but distinct ...
WebApr 8, 2014 · Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signaling. The hominoid …
WebThe ER retention signal of the cytoplasmic domain could not be localized to a single amino acid segment by deletion analysis. These results show that cytochrome P450 2C2 … can i wear moisturizer under sunscreenWebCytosolic retention of phosphorylated extracellular signal-regulated kinase and a Rho-associated kinase-mediated signal impair expression of p21(Cip1/Waf1) in phorbol 12 … five thousand pesos onlyWebMar 21, 2008 · We have determined that the molecular basis for this specialized property of hA3G is a novel cytoplasmic retention signal (CRS) that is necessary and sufficient to restrict wild-type hA3G and chimeric constructs to the cytoplasm. caniwearmypajamastomyoralsurgeryappointmentWebDec 7, 2024 · Due to its potent cytoplasmic retention activity, we named this region (352–357 aa) Cytoplasmic Anchoring Signal, CAS. To further elucidate the working mechanism of the CAS motif, we generated a pair of stable HeLa cell lines that inducibly expressed either the wild type GDOWN1 (WT-Venus) or its CAS mutant ( mCAS -Venus) … five thousand nine hundredWebNov 30, 2007 · However, cytoplasmic reaccumulation after ligand removal, although rapid for GFP-Stat3α (t ½ = 15 min), was markedly delayed for GFP-Stat3β (t ½ > 180 min). Prolonged nuclear retention of Stat3β was accompanied by reduced intranuclear mobility and increased immobile fraction. five thousand seven hundred and twelve poundsWebApr 1, 2006 · Wnt signalling, β-Catenin, Nucleo-cytoplasmic shuttling, FRAP Introduction The canonical Wnt signalling pathway is highly conserved throughout the animal kingdom and regulates crucial steps in cell fate decisions, … five thousand shekels of brass in poundsWebCRS - Cytoplasmic Retention Signal. MRI Magnetic Resonance Imaging. CT Computed Tomography. PCR Polymerase Chain Reaction. HIV Human Immunodeficiency Virus. … five thousand shekels of brass