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Nphs2-cre

Web21 mrt. 2024 · NPHS2 (NPHS2 Stomatin Family Member, Podocin) is a Protein Coding gene. Diseases associated with NPHS2 include Nephrotic Syndrome, Type 2 and … WebPrivate & Exclusive Villas to Rent in Ibiza IbizaSoulLuxuryVillas

Tg(NPHS2-cre/ERT2)#Mkas Transgene Detail MGI Mouse …

WebPierre-Louis Tharaux is Research Professor at INSERM, The Paris Cardiovascular Centre – PARCC, Georges Pompidou European Hospital, AP-HP, Paris and a Visiting Professor at the University Medical Center Hamburg-Eppendorf (Universitätsklinikum Hamburg-Eppendorf - UKE). He obtained an MD at the Paris Descartes University in Paris … Web19 aug. 2024 · 中华儿科杂志2024年第9期遗传性肾病综合征小鼠模型的研究现状. 本论文发表于中华儿科杂志，属于医学相关论文范文材料。. 仅供大家论文写作参考。. ‑00432原发性肾病综合征（nephroticsyndrome，NS）是儿童常见的肾小球疾病，发病率因人种和地区而异，每年（1.15 ... dakota specialty milling fargo https://smileysmithbright.com

Heterozygous expression of Cre recombinase in podocytes has no …

Web10 dec. 2024 · 本发明涉及肾脏足细胞特异敲除lncRNA DLX6‑os1转基因小鼠的培育方法，可有效解决在不同肾脏疾病中研究足细胞损伤的作用机制的问题，其解决的技术方案是，通过基因工程技术对前期建立的携带FLOX‑DLX6‑os1转基因小鼠与另一种携带足细胞特异的NPHS2‑Cre基因的 ... WebNPHS2 pathogenic variants are the most common podocyte gene defects. Yet, pathogenic variants are found only in a minority of SRNS patients. No homozygotes or compound heterozygotes were observed in 377 biopsy confirmed late-onset FSGS [52].In three large worldwide analyses, NPHS2 pathogenic variants were found in roughly 10% of the … Web实验小鼠是目前应用最为广泛的一种实验动物，在探寻基因基础功能，疾病发病机制以及药物临床前筛选等方面有着十分重要的作用。 其原因在于小鼠和人的基因具有极高的相似度（小鼠99%的基因能在人类基因组中找到同源… dakota sda conference

【双荧光报告基因小鼠】织出生物学天空最美丽的彩虹 - 知乎

Category:2012CB517600-G常见肾小球疾病发病机制及其早期诊断

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Nphs2-cre

Tg(NPHS2-cre)295Lbh Transgene Detail MGI Mouse (MGI:2450359)

WebCre/LoxP系统存在几种诱导重组的方式，这是基于Cre重组酶与loxP位点的相互作用而实现的。 当基因组内存在loxP位点时，一旦有Cre重组酶，便会结合到loxP位点两端的反向重复序列区形成二聚体。此二聚体与其他loxP位点的二聚体结合，进而形成四聚体。 WebNphs2-CreERT2 品系全名 C57BL/6JSmoc- Nphs2tm1 (IRES-CreERT2)Smoc 目录号 NM-KI-00128 品系状态 胚胎冻存 加入购物车 导出PDF 基因信息 基因名 Nphs2 基因曾用名 …

Nphs2-cre

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WebFull Sequences from Addgene (1) Based on next-generation sequencing (NGS) results where indicated (Addgene NGS Result), or assembled from reference sequences and/or Sanger results (Addgene Assembled Sequence). Analyze Sequence. GenBank. Web008205 B6.Cg-Tg(NPHS2-cre)295Lbh/J These transgenic mice (commonly referred to as podocin-Cre mice) have expression of Cre recombinase directed to podocytes within kidney glomeruli by the human podocin ( NPHS2 ) promoter/enhancer region and may be useful in generating Cre-lox conditional knockouts for studying the role of podocyte nephrobiology …

http://www.labmodel.cn/mod_product-view-p_id-4397.html Webd, Relative mRNA amount of Fn1, Col1a1 and Col3a1 in control and Ksp cre /Dab2 flox/+ mice with or without FA injection. ... Tory K, et al. Mutation-dependent recessive inheritance of NPHS2-associated steroid-resistant nephrotic syndrome. Nat Genet 46, 299–304 (2014).

WebNphs2.Cre + ;Coq6 flox/flox mutant mice show (A) reduced podocin staining (arrows) appearing only on a few capillary loops (arrow head), whereas (B) nephrin expression is … Web10 jan. 2024 · scRNA-seq of BTBR ob/ob mouse kidneys with early DN. We generated BTBR ob/ob podocyte-reporter mice (BTBR.Cg-Lep ob/ob WiscJ;Gt (ROSA)26Sor tm4(ACTB−tdTomato,−EGFP)Luo;Tg(NPHS2-cre) 295Lbh; hereafter referred to as BTBR ob/ob or DN mice) to investigate the cellular and molecular changes that occur in DN. By …

Web15 aug. 2024 · Rosa26-CreERT2 小鼠种系能够通过体内他莫昔芬诱导对floxed基因表达进行时间控制。. 也就是在Rosa26位点插入了CreERT2基因使其能能够稳定表达，当进行他莫昔芬Tamoxifen给药时，Cre重组酶从细胞质进入细胞核中，作用于loxp位点从而完成条件性基因敲除。. Rosa26位点是 ...

Web赛业生物可为您提供基因敲除、点突变、基因敲入等多种基因编辑大鼠服务，还可为您提供SD、Wistar、Long Evans、F344、Brown Norway大鼠等多种品系选择，致力于为您构建更好的大鼠模型。. 欢迎在线咨询或拨打400-680-8038联系我们。. 使用Cre/loxp系统建立条件 … dakota somerville modelWebNPHS2-cre. 2024-11-19. B6.Cg-Tg(NPHS2-cre)295Lbh. 品系编号：GAP1021. 品系简称：NPHS2-cre. 品系特点：. NPHS2-Cre 小鼠可存活且可生育，Cre 重组酶的表达通过人 … maria storzWeb9 sep. 2024 · The NPHS2-Cre transgene comprises the Cre coding sequence under the control of 2.5 kb of the human NPHS2 promoter. The NPHS2 gene encodes Podocin, which is specifically expressed in podocytes. In their paper, Balkawade et al. observed a thickening of the glomerular basement membrane (GBM) in 24-week-old NPHS2-Cre mice, which … maria stoppel immobilienWebOf note, 2 out of 17 analyzed 2.5P-Cre/ROSA26 mice of founder line #295 did not express significant amounts of -gal in the kidneys. Thus, penetrance of Cre expres-FIG. 1. Transgene construct. A 2.5-kb fragment of the human NPHS2 5 flanking region containing the entire 5 untranslated re-gion was placed in front of a Cre recombinase cassette ... maria stovallWebMutation: Insertion. Mutation details : A 2.5 kb human podocin (NPHS2) promoter (from BAC clone RP11-231PS) was used to drive expression of cre recombinase fused to a … dakota srl psicologiWeb21 mrt. 2024 · NPHS2 (NPHS2 Stomatin Family Member, Podocin) is a Protein Coding gene. Diseases associated with NPHS2 include Nephrotic Syndrome, Type 2 and Nephrotic Syndrome . Among its related pathways are Cell junction organization and Nephrin family interactions . An important paralog of this gene is STOM. UniProtKB/Swiss-Prot … dakota rifle no 10Web本模型可利用Cre/loxP位点特异性重组系统对细胞命运进行追踪展示，揭示特定类型细胞在发育、疾病中的再生、自我更新、分化过程。 双荧光报告基因系统提供zsGreene及tdTomato两种荧光标记，实现了重组/非重组细胞的实时检测，因此，本模型也是一种示踪特异性Cre表达位置的理想工具。 图二 B6-G/R与Cre小鼠交配后部分组织荧光表达检测 好了~以上只是 … dakota sectional sofa